The objective of this study is to investigate the hypolipidemic effects of persimmon fruit on rats fed on high fatdiet. Three groups of male Wister rats were fed on: normal control (NC), high-fat (HF), and high fat supplementedwith whole dried persimmon (Pers/HF, 7%, wt/wt) diets. The results revealed that, the rat’s body weight gain andrelative liver weight were significantly higher in the group fed on HF than the other two groups. The animals fedon diets supplemented with persimmon had improved lipid profile as compared to high fat group. Furthermore, thesupplementation with persimmon induced a significant increase in levels of reduced glutathione and a reduction inmalondialdehyde level when compared to high fat group. In addition, the histopathological examination of the heartand aorta in rats group fed on high fat showed severe histological changes as compared to supplemented persimmongroup, these results reflecting the protective effect of persimmon against atherosclerosis